What genes influence cardiovascular health?

Multiple genetic variants have been identified that are associated with cardiovascular disease. Genofit offers a comprehensive DNA Cardiovascular Health Test that analyzes variants in 27 genes (listed below), which each affect different aspects of cardiovascular health. 

Triglycerides - main form of fat (or lipid) found in the body:

• MLXIPL
• ANGPTL3
• NCAN
• LPL
• TRIB1
• NOS3
• GALNT2

LDL cholesterol - considered “bad” cholesterol:

• APOB
• SORT1
• LDLR
• PCSK9
• SUGP1
• NCAN
• TRIB1
• HMGCR
• HNF1A

HDL cholesterol - considered "good" cholesterol):

• CETP
• LCAT
• LPL
• ANGPTL4
• GALNT2
• LIPG
• MMAB
• HNF4A

Other aspects of cardiovascular health, including lipoprotein(a) levels, lipid metabolism, cell proliferation, and processing of unsaturated fats, are affected by variants in the following genes/regions:

• LPA
• APOA5/A4/C3/A1
• LIPC
• FADS1
• 9p21
• GCKR